Dr.-Ing. Jan-Martin Kuhnigk

  • Member of Management Board
  • Head of Software Development
  • Senior Research Scientist

Publications

2018

Dettmer S, Suhling H, Klingenberg I, Otten O, Kaireit T, Fuge J, Kuhnigk JM, Gottlieb J, Haverich A, Welte T, Wacker F, Vogel-Claussen J, Shin HO (2018) Lobe-wise assessment of lung volume and density distribution in lung transplant patients and value for early detection of bronchiolitis obliterans syndrome. Eur J Radiol 106:137–144

2017

Gallardo Estrella L, Pompe E, Kuhnigk J-M, Lynch DA, Bhatt SP, van Ginneken B, van Rikxoort EM (2017) Computed tomography quantification of tracheal abnormalities in COPD and their influence on airflow limitation. Med Phys 44(7):3594–3603
Lassen-Schmidt BC, Kuhnigk J-M, Konrad O, van Ginneken B, van Rikxoort E (2017) Fast interactive segmentation of the pulmonary lobes from thoracic computed tomography data. Phys Med Biol 62(16):6649–6665

2016

Athelogou M, Kim HJ, Dima A, Obuchowski N, Peskin A, Gavrielides MA, Petrick N, Saiprasad G, Colditz Colditz D, Beaumont H, Oubel E, Tan Y, Zhao B, Kuhnigk J-M, Moltz JH, Orieux G, Gillies RJ, Gu Y, Mantri N, Goldmacher G, Zhang L, Vega E, Bloom M, Jarecha R, Soza G, Tietjen C, Takeguchi T, Yamagata H, Peterson S, Masoud O, Buckler AJ (2016) Algorithm Variability in the Estimation of Lung Nodule Volume From Phantom CT Scans: Results of the QIBA 3A Public Challenge. Acad Radiol 23(8):940–952
Kohlmann P, Boskamp T, Köhn A, Rieder C, Schenk A, Link F, Siems U, Barann M, Kuhnigk J-M, Demedts D, Hahn HK (2016) Remote Visualization Techniques for Medical Imaging Research and Image-Guided Procedures. Visualization in Medicine and Life Sciences III. Springer, pp 133–154
Pompe E, van Rikxoort EM, Mets OM, Charbonnier JP, Kuhnigk JM, de Koning HJ, Oudkerk M, Vliegenthart R, Zanen P, Lammers JJ, van Ginneken B, de Jong PA, Mohamed Hoesein FA (2016) Follow-up of CT-derived airway wall thickness: Correcting for changes in inspiration level improves reliability. Eur J Radiol 85(11):2008–2013

2015

Buckler AJ, Danagoulian J, Johnson K, Peskin A, Gavrielides MA, Petrick N, Obuchowski NA, Beaumont H, Hadjiiski L, Jarecha R, Kuhnigk JM, Mantri N, McNitt-Gray M, Moltz JH, Nyiri G, Peterson S, Tervé P, Tietjen C, von L E, Ma X, St P S, Athelogou M (2015) Inter-Method Performance Study of Tumor Volumetry Assessment on Computed Tomography Test-Retest Data. Acad Radiol 22(11):1393–1408
Doellinger F, Huebner RH, Kuhnigk JM, Poellinger A (2015) Lung Volume Reduction in Pulmonary Emphysema from the Radiologist's Perspective. RöFo Fortschr Röntgenstr 187(8):662–675
Kohlmann P, Strehlow J, Jobst B, Krass S, Kuhnigk JM, Anjorin A, Sedlaczek O, Ley S, Kauczor HU, Wielpütz MO (2015) Automatic lung segmentation method for MRI-based lung perfusion studies of patients with chronic obstructive pulmonary disease. Int J CARS 10(4):403–417
Lassen BC, Jacobs C, Kuhnigk J-M, van Ginneken B, van Rikxoort EM (2015) Robust semi-automatic segmentation of pulmonary subsolid nodules in chest computed tomography scans. Phys Med Biol 60(3):1307–1323
Theilig D, Doellinger F, Kuhnigk JM, Temmesfeld-Wollbrueck B, Huebner RH, Schreiter N, Poellinger A (2015) Pulmonary lymphangioleiomyomatosis: analysis of disease manifestation by region-based quantification of lung parenchyma. Eur J Radiol 84(4):732–737

2014

Heckel F, Meine H, Moltz JH, Kuhnigk J-M, Heverhagen JT, Kießling A, Buerke B, Hahn HK (2014) Segmentation-Based Partial Volume Correction for Volume Estimation of Solid Lesions in CT. IEEE Trans Med Imaging 33(2):462–480
Jacobs C, van Rikxoort EM, Twellmann T, Scholten ET, de Jong PA, Kuhnigk JM, Oudkerk M, de Koning HJ, Prokop M, Schaefer-Prokop C, van Ginneken B (2014) Automatic detection of subsolid pulmonary nodules in thoracic computed tomography images. Med Image Anal 18(2):374–384
Owsijewitsch M, Ley-Zaporozhan J, Kuhnigk J-M, Kopp-Schneider A, Eberhardt R, Eichinger M, Heussel CP, Kauczor H-U, Ley S (2014) Quantitative Emphysema Distribution in Anatomic and Non-anatomic Lung Regions. COPD 12(3):257–266

2013

Lassen B, van Rikxoort EM, Schmidt M, Kerkstra S, van Ginneken B, Kuhnigk J-M (2013) Automatic segmentation of the pulmonary lobes from chest CT scans based on fissures, vessels, and bronchi. IEEE Trans Med Imaging 32(2):210–222
Litzlbauer HD, Weber A, Harth S, Moritz R, Eichner G, Kuhnigk JM, Krass S, Peitgen HO, Krombach GA (2013) Einfluß der Bildrekonstruktion auf die softwarebasierte automatisierte CT- Densitometrie und die Lappensegmentation der Lunge. Fortschr Röntgenstr (Abstract Supplement). VO313_8
Molinari F, Pirronti T, Sverzellati N, Diciotti S, Amato M, Paolantonio G, Gentile L, Parapatt GK, D'Argento F, Kuhnigk JM (2013) Intra- and interoperator variability of lobar pulmonary volumes and emphysema scores in patients with chronic obstructive pulmonary disease and emphysema: comparison of manual and semi-automated segmentation techniques. Diagn Interv Radiol 19(4):279–285
Schaefer A, Kim YJ, Kremp S, Mai S, Fleckenstein J, Bohnenberger H, Schafers H-J, Kuhnigk J-M, Bohle RM, Rube C, Kirsch C-M, Grgic A (2013) PET-based delineation of tumour volumes in lung cancer: comparison with pathological findings. Eur J Nucl Med Mol Imaging 40(8):1233–1244
Schmidt M, van Rikxoort EM, Mets OM, de Jong PA, Kuhnigk J-M, Oudkerk M, de Koning HJ, van Ginneken B (2013) Reproducibility of automated three-dimensional airway wall thickness measurements in thoracic computed tomography and influence of inspiration depth. Annual Meeting of the Radiological Society of North America
Scholten ET, Jacobs C, van Ginneken B, Willemink MJ, Kuhnigk J-M, van Ooijen PMA, Oudkerk M, Mali WPTM, de Jong PA (2013) Computer-Aided Segmentation and Volumetry of Artificial Ground-Glass Nodules at Chest CT. AJR Am J Roentgenol 201(2):295–300
Stoecker C, Welter S, Moltz JH, Lassen B, Kuhnigk JM, Krass S, Peitgen HO (2013) Determination of lung segments in computed tomography images using the Euclidean distance to the pulmonary artery. Med Phys 40(9):091912
Sverzellati N, Kuhnigk J-M, Furia S, Diciotti S, Scanagatta P, Marchiano A, Molinari F, Stoecker C, Pastorino U (2013) CT-based weight assessment of lung lobes: comparison with ex vivo measurements. Diagn Interv Radiol 19(5):355–359
Sverzellati N, Randi G, Spagnolo P, Marchiano A, Silva M, Kuhnigk JM, La Vecchia C, Zompatori M, Pastorino U (2013) Increased mean lung density: Another independent predictor of lung cancer? Eur J Radiol 82(8):1325–1331
van Ginneken B, van Rikxoort EM, Lafebre SJ, Jacobs C, Schmidt M, Kuhnigk J-M, Prokop M, Schaefer-Prokop CM, Charbonnier J-P, Hogeweg L, Maduskar P, Gallardo-Estrella L, Philipsen R, Lassen B (2013) CIRRUS Lung: an optimized workflow for quantitative image analysis of thoracic computed tomography and chest radiography for major pulmonary diseases: chronic obstructive pulmonary disease, lung cancer and tuberculosis. Proc. RSNA 2013

2012

Lassen BC, Schmidt M, van Rikxoort EM, van Ginneken B, Jacobs C, Kuhnigk J-M, Prokop M (2012) Automated and interactive image analysis workstation for the extraction of imaging biomarkers related to chronic obstructive pulmonary disease from thoracic computed tomography scans. Annual Meeting of the Radiological Society of North America
Schmidt M, van Rikxoort EM, Mets OM, de Jong PA, Kuhnigk J-M, van Ginneken B (2012) Automatic Quantification of Airway Dimensions in COPD: Processing Large Databases of Chest CT scans. Annual Meeting of the Radiological Society of North America
Schmidt M, van Rikxoort EM, Mets OM, de Jong PA, Zanen P, Kuhnigk J-M, van Ginneken B (2012) Relating Automatic Quantification of Airway Wall Thickness, Emphysema and Air Trapping in Inspiration and Expiration Chest CT Scans to COPD GOLD Stages. Annual Meeting of the Radiological Society of North America
Sverzellati N, Cademartiri F, Bravi F, Martini C, Gira FA, Maffei E, Marchiano A, La Vecchia C, De Filippo M, Kuhnigk JM, Rossi C, Pastorino U (2012) Relationship and Prognostic Value of Modified Coronary Artery Calcium Score, FEV1, and Emphysema in Lung Cancer Screening Population: The MILD Trial. Radiol 262(2):460–467

2011

Beichel R, de Bruijne M, van Ginneken B, Kabus S, Kiraly A, Kuhnigk JM, McClelland J, Mori K, Reinhardt J, van Rikxoort E, Rit S (2011) Proceedings of the Fourth International Workshop on Pulmonary Image Analysis. CreateSpace
Diciotti S, Sverzellati N, Kauczor H-U, Lombardo S, Falchini M, Favilli G, Macconi L, Kuhnigk J-M, Marchiano A, Pastorino U, Zompatori M, Mascalchi M (2011) Defining the intra-subject variability of whole-lung CT densitometry in two lung cancer screening trials. Acad Radiol 18(11):1403–1411
Grgic A, Ballek E, Fleckenstein J, Moca N, Kremp S, Schaefer A, Kuhnigk JM, Rube C, Kirsch CM, Hellwig D (2011) Impact of rigid and nonrigid registration on the determination of (18)F-FDG PET-based tumour volume and standardized uptake value in patients with lung cancer. Eur J Nucl Med Mol Imaging 38(5):856–864
Lassen B, Kuhnigk JM, Schmidt M, Krass S, Peitgen H-O (2011) Lung and Lung Lobe Segmentation Methods at Fraunhofer MEVIS. Proceedings of the Fourth International Workshop on Pulmonary Image Analysis. pp 185–199
Lassen B, Kuhnigk JM, van Rikxoort EM, Peitgen H-O (2011) Interactive lung lobe segmentation and correction in tomographic images. Proceedings of SPIE Medical Imaging. 79631S:pp 1–8

2010

Lassen B, Kuhnigk JM, Friman O, Krass S, Peitgen H-O (2010) Automatic Segmentation of Lung Lobes in CT Images Based on Fissures, Vessels, and Bronchi. IEEE International Symposium on Biomedical Imaging. pp 560–563
Schmidt M, Kuhnigk JM, Krass S, Owsijewitsch M, de Hoop B, Peitgen H-O (2010) Reproducibility of airway wall thickness measurements. Proceedings of SPIE Medical Imaging. SPIE, 76241O:pp 1–10
Stoecker C, Bornemann L, Dicken V, Krass S, Kuhnigk JM, Zidowitz S, Peitgen H-O (2010) CT-based patient individual anatomical modeling of the lung and its impact on thoracic surgery. In: Dössel O, Schlegel WC (eds) IFMBE Proceedings. IFMBE Proceedings 25(6), pp 1592–1595
Sverzellati N, Ingegnoli A, Calabrò E, Randi G, La Vecchia C, Marchianò A, Kuhnigk JM, Hansell DM, Zompatori M, Pastorino U (2010) Bronchial diverticula in smokers on thin-section CT. Eur Radiol 20(1):88–94

2009

Moltz JH, Bornemann L, Kuhnigk JM, Dicken V, Peitgen E, Meier S, Bolte H, Fabel M, Bauknecht HC, Hittinger M, Kießling A, Püsken M, Peitgen H-O (2009) Advanced Segmentation Techniques for Lung Nodules, Liver Metastases, and Enlarged Lymph Nodes in CT Scans. IEEE J Sel Topics Signal Proc 3(1):122–134
Reeves AP, Jirapatnakul AC, Biancardi AM, Apanasovich TV, Moltz JH, Kuhnigk JM (2009) The VOLCANO´09 Challenge: Preliminary Results. Proceedings of the Second International Workshop on Pulmonary Image Analysis. pp 353–364
Sverzellati N, Calabro E, Randi G, La Vecchia C, Marchiano A, Kuhnigk JM, Zompatori M, Spagnolo P, Pastorino U (2009) Sex differences in emphysema phenotype in smokers without airflow obstruction. Eur Respir J 33:1320–1328

2008

Cohen J, Douma WR, van Ooijen PMA, Willems TP, Dicken V, Kuhnigk J, ten Hacken NHT, Postma DS, Oudkerk M (2008) Localization and Quantification of Regional and Segmental Air Trapping in Asthma. J Comput Assist Tomogr 32(4):562–569
Grgic A, Wilkens H, Kubale R, Kuhnigk JM, Sybrecht GW, Bücker A (2008) Quantitative analysis of volumetric paired thin section multi detector computed tomography scans and pulmonary function tests in patients with severe emphysema. European Society of Thoracic Imaging
Moltz JH, Kuhnigk J-M, Bornemann L, Peitgen H-O (2008) Segmentation of Juxtapleural Lung Nodules in CT Scans Based on Ellipsoid Approximation. Proceeding First International Workshop on Pulmonary Image Analysis. pp 25–32
Moltz JH, Kuhnigk J-M, Bornemann L, Peitgen H-O (2008) Segmentierung pleuraständiger Lungenrundherde in CT-Bildern mittels Ellipsoidapproximation. In: Tolxdorff T, Braun J, Deserno TM, Handels H, Horsch A, Meinzer H-P (eds) Bildverarbeitung für die Medizin. Springer-Verlag, Berlin, Heidelberg, pp 173–177
Sverzellati N, Calabrò E, Randi G, La Vecchia C, Marchianò A, Kuhnigk JM, Spagnolo P, Zompatori M, Pastorino U (2008) Gender differences in emphysema phenotypes in non-COPD smokers. European Society of Thoracic Imaging

2007

Bitter I, van Uitert R, Wolf I, Ibáñez L, Kuhnigk JM (2007) Comparison of Four Freely Available Frameworks for Image Processing and Visualization That Use ITK. IEEE Trans Vis Comput Graph 13(3):483–493
Bolte H, Jahnke T, Schafer FK, Wenke R, Hoffmann B, Freitag-Wolf S, Dicken V, Kuhnigk JM, Lohmann J, Voss S, Knoss N, Heller M, Biederer J (2007) Interobserver-variability of lung nodule volumetry considering different segmentation algorithms and observer training levels. Eur J Radiol 64(2):285–295
Bornemann L, Dicken V, Kuhnigk JM, Wormanns D, Shin H, Bauknecht C, Diehl V, Fabel-Schulte M, Meier S, Kress O, Krass S, Peitgen H-O (2007) OncoTREAT: a software assistant for cancer therapy monitoring. Int J CARS 1(5):231–242
Grgic A, Wilkens H, Kuhnigk JM, Bücker A, Gröschel A, Kubale R, Sybrecht GW (2007) Airway bypass procedure: quantitative low dose multi-detector computed tomography and pulmonary function tests in patients with severe emphysema. European Respiratory Society Meeting. 479s
Müller-Horvat C, Plathow C, Ludescher B, Lichy MP, Canda V, Zindel C, Hahn HK, Peitgen H-O, Kuhnigk J-M, Claussen CD, Schlemmer HP (2007) Generating Statements at Whole-Body Imaging with a Workflow-Optimized Software Tool – First Experiences with Multireader Analysis. RöFo Fortschr Röntgenstr 179(7):721–727
Wilkens H, Grgic A, Kuhnigk JM, Bücker A, Gröschel A, Sybrecht GW (2007) Vergleich von Niedrig-Dosis Mehrzeilen-Computertomographie und Lungenfunktion bei Patienten mit schwerem Lungenemphysem nach Lungenvolumenreduktion durch Exhale Stents. Pneumologie

2006

Beyer F, Heindel W, Hoffknecht P, Kuhnigk JM, Dicken V, Lange T, Thomas M, Wormanns D (2006) CT-Based Software-Supported Prediction of the Postoperative Lung Function after Partial Resection of the Lung. RöFo Fortschr Röntgenstr 178(9):872–879
Bornemann L, Dicken V, Kuhnigk JM, Beyer F, Shin H, Bauknecht C, Diehl V, Fabel-Schulte M, Meier S, Kress O, Krass S, Peitgen H-O (2006) Software Assistance for Quantitative Therapy Monitoring in Oncology. In: Veenland J, Niessen W (eds) Medical Image Processing: Challenges in Clinical Oncology. pp 40–46
Heussel CP, Achenbach T, Buschsieweke C, Kuhnigk JM, Weinheimer O, Hammer G, Düber C, Kauczor HU (2006) Quantification of Pulmonary Emphysema in Multislice-CT Using Different Software Tools. RöFo Fortschr Röntgenstr 178:987–998
Kuhnigk JM, Dicken V, Bornemann L, Bakai A, Wormanns D, Krass S, Peitgen H-O (2006) Morphological Segmentation and Partial Volume Analysis for Volumetry of Solid Pulmonary Lesions in Thoracic CT Scans. IEEE Trans Med Imaging 25(4):417–434
Rexilius J, Kuhnigk JM, Hahn HK, Peitgen H-O (2006) An Application Framework for Rapid Prototyping of Clinically Applicable Software Assistants. In: Hochberger C, Liskowsky R (eds) Lecture Notes in Informatics. Lecture Notes in Informatics P-93, pp 522–528

2005

Bornemann L, Kuhnigk JM, Dicken V, Zidowitz S, Kuemmerlen B, Krass S, Peitgen H-O, Wein B, Schubert H, Shin H, Wormanns D (2005) New tools for computer assistance in thoracic CT – Part II: Therapy monitoring of pulmonary metastases. Radiographics 25(3):841–848
Bornemann L, Kuhnigk JM, Dicken V, Zidowitz S, Wormanns D, Shin H, Krass S, Peitgen H-O (2005) OncoTREAT – A software assistant for oncological therapy monitoring. In: Lemke HU, Inamura K, Doi K, Vannier MW, Farman AG (eds) Proceeding Computer Assisted Radiology and Surgery. Elsevier, Amsterdam, pp 429–434
Dicken V, Kuhnigk JM, Bornemann L, Zidowitz S, Krass S, Peitgen H-O (2005) Novel CT data analysis and visualization techniques for risk assessment and planning of thoracic surgery in oncology patients. In: Lemke HU, Inamura K, Doi K, Vannier MW, Farman AG (eds) Proceeding Computer Assisted Radiology and Surgery. Elsevier, Amsterdam, pp 783–787
Kuhnigk JM, Dicken V, Zidowitz S, Bornemann L, Kuemmerlen B, Krass S, Peitgen H-O, Yuval S, Jend H-H, Rau WS, Achenbach T (2005) New Tools for Computer Assistance in Thoracic CT – Part I: Functional analysis of lungs, lung lobes, and bronchopulmonary segments. Radiographics 25(2):525–536
Wormanns D, Beyer F, Hoffknecht P, Dicken V, Kuhnigk JM, Lange T, Thomas M, Heindel WL (2005) Clinical value of CT-based preoperative software assisted lung lobe volumetry for predicting postoperative pulmonary function after lung surgery. Proc SPIE: Physiology, Function, and Structure from Medical Images. Medical Imaging 2005: Physics of Medical Imaging 5746, pp 78–83

2004

Bornemann L, Dicken V, Kuhnigk JM, Blietz M, Shin H, Wormanns D, Krass S, Peitgen H-O (2004) Ein Werkzeug zur effizienten Quantifizierung des Ansprechens von Lungenmetastasen auf Chemotherapie. In: Tolxdorff T, Braun J, Handels H, Horsch A, Meinzer H-P (eds) Bildverarbeitung für die Medizin. Springer, Berlin, pp 105–109
Kuhnigk JM, Dicken V, Bornemann L, Wormanns D, Krass S, Peitgen H-O (2004) Fast Automated Segmentation and Reproducible Volumetry of Pulmonary Metastases in CT-Scans for Therapy Monitoring. In: Barillot C, Haynor DR, Hellier P (eds) Medical Image Computing and Computer Assisted Intervention. Springer, Berlin, pp 933–941

2003

Dicken V, Wein B, Schubert H, Kuhnigk JM, Krass S, Peitgen H-O (2003) Novel Projection Views for Simplified Reading of Thorax CT Scans with Multiple Pulmonary Nodules. In: Lemke H-U, Vannier MW, Inamura K, Farman AG, Doi K, Reiber JHC (eds) Computer Assisted Radiology and Surgery. Elsevier, Amsterdam, pp 59–64
Dicken V, Wein B, Schubert H, Kuhnigk JM, Krass S, Peitgen H-O (2003) Projektionsansichten zur Vereinfachung der Diagnose von multiplen Lungenrundherden in CT-Thorax Aufnahmen. In: Wittenberg T, et al. (eds) Bildverarbeitung für die Medizin. Springer, Berlin, pp 244–248
Kuhnigk JM, Hahn HK, Hindennach M, Dicken V, Krass S, Peitgen H-O (2003) 3D-Lungenlappen-Segmentierung durch Kombination von Region Growing, Distanz- und Wasserscheiden-Transformation. In: Wittenberg T, et al. (eds) Bildverarbeitung für die Medizin. Springer, Berlin, pp 146–150
Kuhnigk JM, Hahn HK, Hindennach M, Dicken V, Krass S, Peitgen H-O (2003) Lung Lobe Segmentation by Anatomy-Guided 3D Watershed Transform. In: Sonka M, Fitzpatrick JM (eds) Proceedings of SPIE Medical Imaging. SPIE, Bellingham, pp 1482–1490