We develop sound and efficient solutions for rigid, affine, and deformable registration for a wide range of applications and image types. Supported modalities include CT, MR, PET, SPECT, interventional modalities such as CBCT and US, histological H&E and immunohistochemical stains, as well as preclinical and biological modalities like spectral MALDI imaging and light sheet fluorescence microscopy (LSM/SPIM).