Dr. Hendrik Laue

  • Senior Research Scientist
  • Dynamic Imaging
  • Quantitative Imaging



Budelmann D, Qing C, Laue HOA, Albadry M, Dahmen U, Schwen LO (2023) Segmentation of Lipid Droplets in Histological Images. MIDL
Laue HOA, Persigehl T (2023) Editorial for “Computed DWI Results in Superior Capability for N-Stage Assessment of Non-Small Cell Lung Cancer than that of Actual DWI, STIR Imaging and FDG-PET/CT”. J Magn Reson Imaging 57(1):273–274
Schultz B, DeLong LN, Masny A, Lentzen M, Raschka T, van Dijk D, Zaliani A, Hansen AF, Sabine, Rüping KS, Burmeister J, Kohlhammer J, Sarau G, Christiansen S, Kannt A, Zaliani A, Foldenauer AC, Claussen C, Resch E, Frank K, Gribbon P, Kuzikov M, Keminer O, Laue H, Hahn H, Hirsch J, Wischnewski M, Günther M, Archipovas S, Kodamullil AT, Gemünd A, Schultz B, Steinborn C, Ebeling C, Fernández DD, Hermanowski H, Fröhlich H, Klein J, Lentzen M, Jacobs M, Hofmann-Apitius M, Knieps M, Krapp M, Wendland PJ, Wegner P, Khatami SG, Springstubbe S, Linden T, Fluck J, Fröhlich H (2023) A machine learning method for the identification and characterization of novel COVID-19 drug targets. Sci Rep 13(1)
Vignon-Clementel IE, Jagiella N, Dichamp J, Kowalski J, Lederle W, Laue H, Kiessling F, Sedlaczek O, Drasdo D (2023) A proof-of-concept pipeline to guide evaluation of tumor tissue perfusion by dynamic contrast-agent imaging: Direct simulation and inverse tracer-kinetic procedures. Front Bioinform 3


Albadry M, Höpfl S, Ehteshamzad N, König M, Böttcher M, Neumann J, Lupp A, Dirsch O, Radde N, Christ B, Christ M, Schwen LO, Laue H, Klopfleisch R, Dahmen U (2022) Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism. Sci Rep 12(21825)
Budelmann D, Laue H, Weiss N, Dahmen U, D’Alessandro LA, Biermayer I, Klingmüller U, Ghallab A, Hassan R, Begher-Tibbe B, Hengstler JG, Schwen LO (2022) Automated Detection of Portal Fields and Central Veins in Whole-Slide Images of Liver Tissue. J Pathol Inform 13:100001
Weber J-PD, Spiro JE, Scheffler M, Wolf J, Nogova L, Tittgemeyer M, Maintz D, Laue H, Persigehl T, Baltzer PAT (2022) Reproducibility of dynamic contrast enhanced MRI derived transfer coefficient Ktrans in lung cancer. PLoS ONE 17(3):e0265056


Bliesener Y, Zhong X, Guo Y, Boss M, Bosca R, Laue H, Chung C, Sung K, Nayak KS (2019) Radiofrequency transmit calibration: A multi-center evaluation of vendor-provided radiofrequency transmit mapping methods. Med Phys 46(6):2629–2637
Shukla-Dave A, Obuchowski NA, Chenevert TL, Jambawalikar S, Schwartz LH, Malyarenko D, Huang W, Noworolski SM, Young RJ, Shiroishi MS, Kim H, Coolens C, Laue H, Chung C, Rosen M, Boss M, Jackson EF (2019) Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE-MRI derived biomarkers in multicenter oncology trials. J Magn Reson Imaging 49(7):e101–e121


Oei MTH, Meijer FJA, Mordang J-J, Smit EJ, Idema AJS, Goraj BM, Laue HOA, Prokop M, Manniesing R (2018) Observer variability of reference tissue selection for relativecerebral blood volume measurements in glioma patients. Eur Radiol 28(9):3902–3911
Strehlow J, Spahr N, Rühaak J, Laue H, Abolmaali N, Preusser T, Schenk A (2018) Landmark-based evaluation of a deformable motion correction for DCE-MRI of the liver. Int J CARS 13(4):597–606


Hillengass J, Ritsch J, Merz M, Wagner B, Kunz C, Hielscher T, Laue H, Bauerle T, Zechmann CM, Ho AD, Schlemmer H-P, Goldschmidt H, Moehler TM, Delorme S (2016) Increased microcirculation detected by dynamic contrast-enhanced magnetic resonance imaging is of prognostic significance in asymptomatic myeloma. Br J Haematol 174(1):127–135
Honroth T, Vreeman S, Vicari M, Laue H, Mann R, Guenther M (2016) 3D Arterial Spin Labeling in breast cancer: A case study. Proceedings of the 24th Annual Meeting ISMRM. 1489
Laue H, Persigehl T, Kohlmann P, Giesel FL, Strehlow J, Schenk A (2016) A Software for Quantitative Liver DCE and DWI-MRI to Support Treatment Monitoring in Liver Cancer and Metastasis. Radiological Society of North America. QRR005
Lotz J, Olesch J, Müller B, Polzin T, Galuschka P, Lotz JM, Heldmann S, Laue H, González-Vallinas M, Warth A, Lahrmann B, Grabe N, Sedlaczek O, Breuhahn K, Modersitzki J (2016) Patch-Based Nonlinear Image Registration for Gigapixel Whole Slide Images. IEEE Transactions on Biomedical Engineering 63(9):1812–1819
Lotz J, Olesch J, Müller B, Polzin T, Galuschka P, Lotz JM, Heldmann S, Laue H, Warth A, Lahrmann B, Grabe N, Sedlaczek O, Breuhahn K, Modersitzki J (2016) Patch-Based Nonlinear Image Registration for Gigapixel Whole Slide Images. IEEE Trans Biomed Eng 63(9):1812–1819
Manka L, Schiffmann H, Thiele H, Randazzo M, Kwiatkowski M, Hiber D, Gassler N, Sperling M, Hammerer P, Lotz J, Laue H (2016) ProHistoMRI®: Proof of Principle – MRT/Histopathologische Fusion – Ein neuer Schritt in der Evaluation der MRT Diagnostik beim Prostatakarzinom. Kongress der Deutschen Gesellschaft für Urologie
Merz M, Moehler TM, Ritsch J, Bauerle T, Zechmann CM, Wagner B, Jauch A, Hose D, Kunz C, Hielscher T, Laue H, Goldschmidt H, Delorme S, Hillengass J (2016) Prognostic significance of increased bone marrow microcirculation in newly diagnosed multiple myeloma: results of a prospective DCE-MRI study. Eur Radiol 26(5):1404–1411
Yoon JH, Choi J-I, Jeong YY, Schenk A, Chen L, Laue H, Kim SY, Lee JM (2016) Pre-treatment Estimation of Future Remnant Liver Function using Gadoxetic acid MRI in Patients with HCC. J Hepatol 65(6):1155–1162


Laue H, Lotz J, Kohlmann P, Sedlaczek O, Hahn HK (2015) A software tool for aligning and linking morphological CT, quantitative DCE- and DWI-MRI with morphological CT and 3D pathology in lung cancer staging and tumor biology. Radiological Society of North America. QRR008
Laue H, Kohlmann P, Lotz J, Sedlaczek O, Müller B, Breuhahn K, Grabe N, Warth A, Hahn HK (2015) Software Support for Combined Staging of Lung Cancer in CT, Functional MRI and Pathology. Proc. of the 16th World Conference on Lung Cancer
Razavi M, Wang L, Gubern-Mérida A, Ivanovska T, Laue H, Karssemeijer N, Hahn HK (2015) Towards Accurate Segmentation of Fibroglandular Tissue in Breast MRI Using Fuzzy C-Means and Skin-Folds Removal. Proc. Image Analysis and Processing — ICIAP 2015. pp 528–536
Wang L, Strehlow J, Ruehaak J, Weiler F, Diez Y, Gubern-Mérida A, Diekmann S, Laue H, Hahn HK (2015) A fast alignment method for breast MRI follow-up studies using automated breast segmentation and current-prior registration. Proceedings of SPIE Medical Imaging: Image Processing. 941334:pp 1–8
Zhang T, Chen CH, Barboriak D., Laue HOA (2015) QIBA DRO Evaluation Tool for assesing Analysis Software Quantification and identifying Error Source for the General Kinetic Model. Radiological Society of North America (RSNA). in print


Laue HOA, Kohlmann P, Dicken V, Moltz J, Sedlaczek O, Olesch J, Lotz J, Kikinis R, Hahn HK (2014) An application for comparing quantitative DCE- and DWI-MRI with pathology supporting investigators correlating radiology, pathology and tumor biology in lung cancer. Annual Meeting Radiological Society of North America (RSNA). QRR005
Lotz J, Berger J, Müller B, Breuhahn K, Grabe N, Heldmann S, Homeyer A, Lahrmann B, Laue H, Olesch J, Schwier M, Sedlaczek O, Warth A (2014) Zooming in: High Resolution 3D Reconstruction of Differently Stained Histological Whole Slide Images. Proceeding of SPIE Medical Imaging: Digital Pathology. 904104:pp 1–7
Schenk A, Chen L, Yoon JH, Lee JM, Bergmann K, Laue HOA, Strehlow J, Schumann C, Demedts D, Hahn HK (2014) Combined analysis of dynamic Gd-EOB-DTPA-enhanced MRI and local volume computation for quantitative liver function evaluation. Annual Meeting Radiological Society of North America (RSNA). QRR004
van den Boom R, Manniesing R, Oei MTH, van der Woude W-J, Smit EJ, Laue HOA, van Ginneken B, Prokop M (2014) A 4D digital phantom for patient-specific simulation of brain CT perfusion protocols. Med Phys 41(7):071907


Laue HOA, Oei MTH, Chen L, Kompan IN, Hahn HK, Prokop M, Mannesing R (2013) Automated artery and vein detection in dynamic CT data with an unsupervised classification algorithm of the time intensity curves. Proceedings of SPIE Medical Imaging. 86691W:pp 1–6


Hansch A, Kohlmann P, Hinneburg U, Boettcher J, Malich A, Wolf G, Laue H, Pfeil A (2012) Quantitative evaluation of MR perfusion imaging using blood pool contrast agent in subjects without pulmonary diseases and in patients with pulmonary embolism. Eur Radiol 22(8):1748–1756


Breckling B, Laue H, Pehlke H (2011) Remote sensing as a data source to analyse regional implications of genetically modified plants in agriculture--Oilseed rape (Brassica napus) in Northern Germany. Ecol Indicators 11(4):942–950
Kohlmann P, Laue H, Krass S, Peitgen H-O (2011) Fully-automatic determination of the arterial input function for dynamic contrast-enhanced pulmonary MR imaging. Proceedings of Medical Image Understanding and Analysis. pp 281–285
Kompan IN, Prieto C, Knowles BR, Laue H, Charles-Edwards G, Guenther M, Schaeffter T (2011) Analysis of signal-adaptive k-space acquisition schemes in quantitative dynamic contrast-enhanced MRI. Proceedings of the 19th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM)
Ritter F, Boskamp T, Homeyer A, Laue H, Schwier M, Link F, Peitgen H-O (2011) Medical image analysis. IEEE Pulse 2(6):60–70