Dr. Lars Ole Schwen

  • Modeling
  • Simulation
  • Image Guided Therapy



Budelmann D, Laue H, Weiss N, Dahmen U, D’Alessandro LA, Biermayer I, Klingmüller U, Ghallab A, Hassan R, Begher-Tibbe B, Hengstler JG, Schwen LO (2022) Automated Detection of Portal Fields and Central Veins in Whole-Slide Images of Liver Tissue. Journal of Pathology Informatics 13
Schwen LO, Schacherer D, Geißler C, Homeyer A (2022) Evaluating generic AutoML tools for computational pathology. Inform Med Unlocked 29:100853


Homeyer A, Lotz J, Schwen LO, Weiss N, Romberg D, Höfener H, Zerbe N, Hufnagl P (2021) Artificial intelligence in pathology: From prototype to product. J Pathol Inform 12(1):13


Georgii J, Pätz T, Rieder C, Ballhausen H, Schwenke M, Schwen LO, Haase S, Preusser T (2020) Efficient GPU-Based Numerical Simulation of Cryoablation of the Kidney. In: Miller K, Wittek A, Joldes G, Nash M, Nielsen P (eds) Computational Biomechanics for Medicine. Springer, Cham, pp 171–193
Rieder C, Schwenke M, Pätz T, Georgii J, Ballhausen H, Schwen LO, Haase J, Preusser T (2020) Evaluation of a numerical simulation for cryoablation – comparison with bench data, clinical kidney and lung cases. Int J Hyperthermia 37(1):1268–1278
Schwen LO (2020) Ten simple rules for typographically appealing scientific texts. PLOS Computational Biology 16(12):e1008458


Homeyer A, Hammad S, Schwen LO, Dahmen U, Höfener H, Gao Y, Dooley S, Schenk A (2018) Focused scores enable reliable discrimination of small differences in steatosis. Diagn Pathol 13(76):1–9
Schwen LO, Rueschenbaum S (2018) Ten quick tips for getting the most scientific value out of numerical data. Plos Comp Biol 14(10):e1006141
Schwen LO, Andersson A, Korski K, Weiss N, Haase S, Gaire F, Hahn HK, Homeyer A, Grimm O (2018) Data-Driven Discovery of Immune Contexture Biomarkers. Front Oncol 8(627):1–15


Christ B, Dahmen U, Herrmann K-H, König M, Reichenbach JR, Ricken T, Schleicher J, Schwen LO, Vlaic S, Waschinsky N (2017) Computational Modeling in Liver Surgery. Front Physiol 8:906
Schenk A, Ghallab A, Hofmann U, Hassan R, Schwarz M, Schuppert A, Schwen LO, Braeuning A, Teutonico D, Hengstler JG, Kuepfer L (2017) Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage. Sci Rep 7:6224
Schwen LO, Kuepfer L, Preusser T (2017) Modeling approaches for hepatic spatial heterogeneity in pharmacokinetic simulations. Drug Discovery Today: Disease Models 22(2016):35–43


Schwen LO, Homeyer A, Schwier M, Dahmen U, Dirsch O, Schenk A, Kuepfer L, Preusser T, Schenk A (2016) Zonated quantification of steatosis in an entire mouse liver. Comput Biol Med 73:108–118
Xie C, Schwen LO, Wei W, Schenk A, Zafarnia S, Gremse F, Dahmen U (2016) Quantification of Hepatic Vascular and Parenchymal Regeneration in Mice. PLoS ONE 11(8):1–19
Xie C, Wei W, Schenk A, Schwen LO, Zafarnia S, Schwier M, Gremse F, Jank I, Dirsch O, Dahmen U (2016) Visualization of Vascular and Parenchymal Regeneration After 70% Partial Hepatectomy in Normal Mice. JoVE 115(e53935):1–6


Gremse F, Höfter A, Schwen LO, Kiessling F, Naumann U (2015) GPU-Accelerated Sparse Matrix-Matrix Multiplication by Iterative Row Merging. SIAM J Sci Comput 37(1):C54–C71
Saenger C, Schenk A, Schwen LO, Wang L, Gremse F, Zafarnia S, Kiessling F, Xie C, Wei W, Richter B, Dirsch O, Dahmen U (2015) Intrahepatic Vascular Anatomy in Rats and Mice—Variations and Surgical Implications. PLoS ONE 10(11):e0141798
Schwen LO, Pätz T, Preusser T (2015) Some Use Cases for Composite Finite Elements in Image Based Computing. In: Joldes GR, Doyle B, Wittek A, Nielsen PMF, Miller K (eds) MICCAI 2015 Workshop Proceedings Computational Biomechanics for Medicine X. pp 128–140
Schwen LO, Schenk A, Kreutz C, Timmer J, Bartolomé Rodriguez MM, Kuepfer L, Preusser T (2015) Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations. PLoS ONE 10(7):e0133653
Schwen LO, Wei W, Gremse F, Ehling J, Wang L, Dahmen U, Preusser T (2015) Algorithmically Generated Rodent Hepatic Vascular Trees in Arbitrary Detail. J Theor Biol 365:289–300


Schwen LO, Wolfram U (2014) Validation of Composite Finite Elements Efficiently Simulating Elasticity of Trabecular Bone. Comput Methods Biomech Biomed Engin 17(6):652–660
Schwen LO, Krauss M, Niederalt C, Gremse F, Kiessling F, Schenk A, Preusser T, Kuepfer L (2014) Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver. PLoS Comput Biol 10(3):e1003499


Schwen LO, Preusser T (2012) Analysis and Algorithmic Generation of Hepatic Vascular Systems. Int J Hepatol 2012(Article ID 357687):1–17
Schwen LO, Pätz T, Preusser T (2012) Composite Finite Element Simulation of Radio Frequency Ablation and Bone Elasticity. In: Eberhardsteiner J, et al (eds) Proceedings of the 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS2012)


Preusser T, Rumpf M, Sauter S, Schwen LO (2011) 3D composite finite elements for elliptic boundary value problems with discontinuous coefficients. SIAM J Sci Comput 33(5):2115–2143